OmniRayn · Foundry Classroom · Flagship ★

Run the
Falsification

Your class moves a real candidate up the evidence ladder.

Instructors Students · lab
01
OmniRayn/Run the Falsification
InstructorsStudents
The candidate

Spermidine — an autophagy/mitophagy inducer.

Why it's safe to teach

Commercially available, tox-clean — teaching-lab-grade.

The prediction

Induces cellular cleanup → predicted cytoprotective for neurons.

The opening

Whitespace for Parkinson's — untried. Sitting on rung one.

02
OmniRayn/Run the Falsification
InstructorsStudents
The pre-registered assay

A protocol built for a teaching lab.

Cells
SH-SY5Y
Human neuron-like line.
Insult
Rotenone
Models Parkinson's-type stress.
Treatment
Spermidine dose-response
A range, not one dose.
Readout
CellTiter-Glo
Luminescent viability.
Controls — vehicle · insult-only · NAC (positive) teaching-lab-grade
03
OmniRayn/Run the Falsification
InstructorsStudents
Pre-register — before you run

Lock the PASS criteria before the first well.

≥ 30%

Dose-dependent protection vs. the insult-only control.

p < 0.05

Statistically significant, not eyeballed.

× 2 runs

Reproduced independently. No moving the goalposts.

04
OmniRayn/Run the Falsification
InstructorsStudents
The honesty rule

A FAIL is recorded too. Negatives count.

An honest conversion rate needs the misses. A pipeline that only reports its wins is lying with statistics — so falsifying a hypothesis is a real contribution, not a wasted semester.

05
OmniRayn/Run the Falsification
The flywheel
Upload

Your result moves the listing one rung up.

Hypothesis Community-reported

Honesty flag: backend + review gate are built; the public upload portal is launching, not live — pending consent + data agreements.

06
OmniRayn/Run the Falsification
InstructorsStudents
The promotion gate

Why the bar to "validated" is high.

To promote a listing
  • ≥ 2 independent PASS runs, different labs
  • A reviewer sign-off on the evidence
Community-reported In-vitro-validated

Reproducibility isn't bureaucracy — it's what separates a finding from a fluke.

07
OmniRayn/Run the Falsification
InstructorsStudents
What students walk away with

Skills, a contribution, and their name on it.

Real bench skills

Cell culture, dose-response design, a viability assay, proper controls.

A real contribution

A publishable result on a live candidate — not a canned exercise.

Attribution

Their name on the record of the listing they moved.

08
OmniRayn/Run the Falsification
Non-commercial · MTA
The license

"Computational predictions, pending wet-lab; structure-function framing only; not experimental evidence and not a disease, treatment, or efficacy claim."

Contributions run under an institutional agreement with attribution and a data-contribution agreement / MTA. The upload portal is launching, not live.

09