S2 (505(b)(2))

congestive heart failure

Library compounds whose LINCS consensus expression profiles most strongly anti-correlate one transcriptional signature associated with congestive heart failure, after a cytotoxicity-alignment filter and clinical-maturity ranking. Compounds our structural screen flags are labelled below rather than hidden. This is a property of that signature, not of the disease. Computational and hypothesis-generating, pending wet-lab. Method & limits →

Not tested. Twenty-three indications in our corpus hold two independently derived signatures. Comparing the twelve top candidates from each: 14 pairs shared no compound, 6 shared one, 3 shared two — indistinguishable from the 3,173 pairs built from different indications, where 60.1% likewise share nothing (p = 0.92, two-sided). But in every one of those pairs one signature was far too shallow to measure anything, so that outcome was expected before the test was run. It is not evidence that the method fails; it is evidence that we never ran a test capable of succeeding. Treat the names below as leads from one measurement, not as candidates for the disease.

Ranking withheld — non-human signature

The expression signature behind this page was measured in mouse, not in human tissue. Its gene symbols were mapped onto the human landmark space by uppercasing, which is a crude substitution and not an ortholog mapping. We are not ranking or selling candidates derived from a cross-species signature. The candidate names above are shown for transparency and are not ordered by a trustworthy score.

How the score works & its limits →