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DossierHypothesis

Cordycepin (Cordyceps militaris) — genome-discovered natural product dossier

A genotype→chemotype prediction from the engine's fungal-BGC caller: it identifies the Cns1–4 cluster in the Cordyceps militaris genome and predicts cordycepin as the product. Cordycepin is a known, off-patent natural product — this dossier is the COMPUTATIONAL prediction of what the genome can make, PENDING WET-LAB confirmation (ferment, isolate, confirm by HPLC vs an authentic cordycepin standard).

Research intelligence — a ranked, filtered hypothesis, not a validated cure. No disease or efficacy claim. Computational transcriptomic prediction, pending wet-lab.

Mechanism
Genome-to-compound: the cordycepin/pentostatin biosynthetic gene cluster (Cns1–4) called from the Cordyceps militaris genome → cordycepin (3'-deoxyadenosine)
Validation state
Hypothesis — Computational transcriptomic prediction. Pending wet-lab. The engine's default output.
Tox gate
Flagged
Trial whitespace
Whitespace unknown — Known compound (first described 1950); off-patent. Composition IP is weak — the value is the genome-discovery method and a reproducible biomanufacturing route, not the molecule.
IP class
Natural product — GRAS/food/NP — supplement (Lane B) eligible.
Headline

Genome → BGC (Cns1–4) → cordycepin · computational prediction, pending wet-lab · public off-patent natural product · a genotype→chemotype teaching case

Computational hypothesis· 2026-06-27
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The full dossier — ranked candidate lists, measured-selectivity detail, published-literature corroboration, and known-compound structures — is delivered as a PDF to your checkout email. The teaser and the free academic package above are always public.

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Provenance: Real artifact: fungal-BGC caller on the Cordyceps militaris genome (cordycepin/pentostatin Cns1–4 cluster; recovered via classify-not-filter). Cordycepin structure is public prior art. Computational genotype→chemotype prediction — PENDING WET-LAB. · Updated 2026-06-27.
Research intelligence, not medical, efficacy, or freedom-to-operate advice. All candidate signals are computational transcriptomic predictions pending wet-lab validation. The subscriber owns development and claims decisions and is responsible for its own freedom-to-operate. CONFIDENTIAL — MightyCloud Collective / OmniRayn Foundry.