Mechanism screenHypothesis

Selective mitochondrial-function inducers — clinically untried

Compounds ranked by global-normalized, cytotox-corrected upregulation of a landmark mito-function gene set (HDACi-confounder removed).

Research intelligence — a ranked, filtered hypothesis, not a validated cure. No disease or efficacy claim. Computational transcriptomic prediction, pending wet-lab.

Mechanism

Mitochondrial-function induction (SDHB / SIRT3 / NRF2 / HSPD1 / DLD / ANT1 / TOMM34)

Validation state

Hypothesis — Computational transcriptomic prediction. Pending wet-lab. The engine's default output.

Tox gate

Clean (Brenk/PAINS/NIH + cytotox + carcinogen blocklist)

Trial whitespace

Untried (whitespace) — Mechanism is not an FDA disease indication — almost no interventional trials target it directly.

IP class

Known drug — Approved/clinical compound. Intelligence only — no compound IP conveyed.

Headline

~5,000 LINCS compounds scored · top selective mito-inducers, cytotox-gated

Computational hypothesis· 2026-06-02

Related listings

Same mechanism or overlapping tags. Computational, pending wet-lab.

Selective reversal of a cellular-senescence gene-expression program

Senescence-program selective reverser — target-engagement confirmed

Validation-state demonstration · in-vitro target-engagement confirmed · still pending efficacy

Selective reversal of an aging (GSE107037) gene-expression program

Caffeic-acid phenethyl ester (CAPE) — aging-program reverser dossier

Propolis-derived NP · selective aging-program reverser · DSHEA structure-function candidate

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Provenance: Real artifact: _hetzner_mito_screen2.py (global-normalized mito-induction screen). Exact ranked values pending re-export; headline counts illustrative. · Updated 2026-06-02.
Research intelligence, not medical, efficacy, or freedom-to-operate advice. All candidate signals are computational transcriptomic predictions pending wet-lab validation. The subscriber owns development and claims decisions and is responsible for its own freedom-to-operate. CONFIDENTIAL — MightyCloud Collective / OmniRayn Foundry.